Effect of Exogenous Estrogen during Pregnancy on the Development of the Testis of Rats. Histological Considerations and Clinical Implications
Metwally Abd-El-Bary Mnsoor
Anatomy Department, Faculty of Medicine, Zagazig University
Abstract: Background: Testicular dysgenesis syndrome is a result of disruption of embryonal programming and gonadal development during fetal life. In recent years, evidences have accumulated that exposure to environmental components with estrogenic activity causes reproductive disorders in human population.Objective: The study was carried out to evaluate the testicular hazards of the neonatal rats resulting from exposure of their pregnant mothers to estrogenic compounds. Subjects: Two primary groups, each consisted of 3 adult male and 12 adult female rats were used. After mating, two secondary groups, each consisted of 6 pregnant rats were divided into control group injected with saline and treated one, subcutaneously injected with oestradiol benzoate 100 mg/kg. body weight/day from the 13th day of pregnancy onwards. Results: There is marked decrease in seminiferous tubules of the testis. Some tubules are incompletely formed with blood cells in interstitial tissue of the testis. The nuclei of spermatogenic cells are markedly affected beginning from disturbance in their shapes and chromatin distribution, to pyknosis, to complete disappearance. Their cytoplasm was vacuolated. Sertoli cells showed vacuolation of their cytoplasm and the nuclei of Leydig cells are more heterochromatic. Conclusion: Estrogenic compounds administered to pregnant mothers produce marked histological hazards in the testes of their neonates and so, estrogenic compounds must be avoided as possible during pregnancy.
[Metwally Abd-El-Bary Mnsoor. Effect of Exogenous Estrogen during Pregnancy on the Development of the Testis of Rats. Histological Considerations and Clinical Implications. J Am Sci 2013;9(6):245-250]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 28
Key words: Oestradiol, Testis, Histological study, Albino rats. Full Text 28