'Synthesis and Biological Assessment of Some New Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents'
Azza Taher Taher
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini street, Cairo, P.O. Box, 11562, Egypt. email@example.com
Abstract: A series of novel acrylonitrile derivatives 4-10 have been synthesized and characterized by spectral data. Thein-vitro antitumor activity of all compounds was assessed in the MCF-7 human breast cancer cell line. The results showed that compound 8a exhibited promising anticancer activity with IC50 = 9.92 µg/mL while, compounds 4b, 4c, 7b,8c and 10b possessed significant cytotoxic effect with IC50 ranging 15.64-20.76 µg/mL. The final targets were also tested for their antimicrobial activity. The results revealed that compounds 4a, 5b, 8a and 8c showed remarkable broad spectrum antimicrobial activity, while compounds 5c, 8a and 8c displayed high antifungal activity against candida albicans in comparison with amphotericin B reference drug (IC50 = 9.30, 6.25 and 2.30 µg/mL, respectively).
[Azza Taher Taher. Synthesis and Biological Assessment of Some New Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents. Life Sci J 2012;9(1):991-1005] (ISSN:1097-8135). http://www.lifesciencesite.com. 143
Keywords: Acryloylnitrile; Synthesis; Antitumor; antimicrobial activities. Full Text 143