Apelin and PDCD5 levels in patients with chronic heart failure
Guojie Yang1, Quanhe Wang1, Nan Wu1, Zihan Wei1
Department of geriatrtic cardiology, the fisrt affiliated hospital of Zhengzhou University, Zhengzhou, Henan450052, China
Abstracts: Objective: To detect the plasma levels of apelin and Programed Cell Death 5(PDCD5) antibody in elderly patients with chronic heart failure. Methods: Forty patients with chronic heart failure were divided into 3 groups CHF according to NYHA class II~IV, and twenty normal volunteers were enrolled．Plasma levels of apelin and PDCD5 antibody were detected by enzyme-linked immunosorbent assay. Results: (1)The plasma levels of apelin in patients with heart failure(NYHA class Ⅱ~Ⅳ) were significantly lower than that in control group,and it was lower in NYHA class Ⅲ-Ⅳ groups than that in NYHA classⅡ group (P <0.05); (2) The plasma levels of PDCD5 were increased in CHF patients(P <0.05). Conclusion: Detecting the plasma levels of apelin and PDCD5 antibody might be usful to evaluate the heart functon.
[Guojie Yang, Quanhe Wang, Nan Wu, Zihan Wei. Apelin and PDCD5 levels in patients with chronic heart failure. Life Sci J 2013:10(1):3180-3182]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
Key words: heart failure；apelin；PDCD5.