Carbonic Anhydrase and Urease Inhibitory Effects of Sonchus Asper
Ihsan Ullah Khan1, Jameel A. Khader2 , Farman Ullah Khan3, Arif Ullah Khan4, Muhib Ullah5, Syed Badshah3,Naser M. AbdEIslam2, Hidayatullah Khan6, Riaz Ullah7*
1Department of Chemistry, Quaid-e-Azam University Islamabad Pakistan
2Arriyadh Community College, King Saud University, Riyadh, Saudi Arabia
3Department of Chemistry, University of Science and Technology Bannu -28100, KPK, Pakistan
4Department of Pharmacy, Kohat University of Science and Technology Kohat KPK, Pakistan
5Department of Zoology, Kohat University of Science and Technology Kohat, KPK Pakistan
6Department of Biotechnology, University of Science and Technology Bannu -28100, KPK, Pakistan
7Department of Chemistry, Sarhad University of Science and Information Technology Peshawar KPK Pakistan
Corresponding author; Dr Riaz Ullah. firstname.lastname@example.org
Abstract: In present research, an attempt was made to explore the pharmacological potential of Sonchus asper. The crude extract of Sonchus asper and its resultant fractions were tested for the carbonic annhydrase and urease inhibitory actions. The chloroform fraction of Sonchus asper exhibited maximum carbonic anhydrase II inhibition of 58.0%, followed by the plant crude extract, n-hexane fraction and aqueous fraction with 42.6, 30.2 and 21.3% inhibition respectively. In urease inhibitory bioassays, n-hexane fraction possesses highest urease inhibition capacity of 24.1%, followed by chloroform fraction (19.1%), crude extract (5.4%) and aqueous fraction (3.4%). These results indicate that Sonchus asper exhibits carbonic anhydrase and urease inhibitory activities. The higher carbonic anhydrase and urease inhibitory profile observed respectively for chloroform and n-hexane fractions of Sonchus asper propose concentration of respective active compounds, which warrants further detail studies for their isolation and molecular identification. [Ihsan Ullah Khan, Jameel A. Khader , Farman Ullah Khan, Arif Ullah Khan, Muhib Ullah, Syed Badshah, Naser M. AbdEIslam, Hidayatullah Khan, Riaz Ullah. Carbonic Anhydrase and Urease Inhibitory Ef fects of Sonchus Asper. Life Sci J2013;10(1):2705-2707] (ISSN:1097-8135). http://www.lifesciencesite.com.
Key words: Sonchus asper, carbonic anhydrase, and urease inhibition.