Cytotoxic activity of Buddleja asiatica
Mona Mohamed*1, Allia Abdou1, Amal Saad1, Magda Ibrahim2
1Medicinal Chemistry Department, Theodor Bilharz Research Institute (TBRI),
2Pharmcognosy Department, Azhar University
Abstract: Phytochemical investigations of Buddleja asiatica leaves have led to the isolation of a new compound: 3,4 dihydroxy phenylethyl alcohol 8-O[(4'-O-feruoyl)-α-L-rhamnopyranosyl-(1''→3') –β-D-glucopyranosyl-(1'''→6')]- β-D-glucopyranoside 1, along with 5 known metabolites: E-acteoside, E-iso acteoside, rutin, trimethoxy luteolin and ajugol. All metabolites were isolated for the first time from the genusBuddleja. The structures were determined by spectroscopic methods (UV, ESI-MS, 1H, 13CNMR, 1H-1H COSY, HSQC, and HMBC). The investigated methanol extract and compounds (1-4) showed significant cytotoxic activity against a HepG2 cell line.
[Mona Mohamed, Allia Abdou, Amal Saad,and Magda Ibrahim. Cytotoxic activity of Buddleja asiatica. Life Sci J 2013; 10 (1):2773-2777]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
Key words: Buddleja asiatica, Cytotoxic, HepG2.