Guggul Resin Extract Improve hyperglycemia and Lipid Profile in Streptozotocin Induced Diabetes Mellitus in rats
Widad M. Al- Bishri1, Omar S. Al-Attas 2, 3
1Department of Biochemistry, Sciences Faculty for Girls, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2Department of Biochemistry, College of Science, Po Box 2455, King Saud University, Riyadh 11451, Saudi Arabia
3Center of Excellence in Biotechnology Research, Po Box 2460, King Saud University, Riyadh 11451, Saudi Arabia
Abstract: Natural products is an affective approach for the treatment of diabetes and prevention of associated complications. The objective of the current study is to explore the potential impact of guggul resin aqueous extract (GRE) obtained from Commiphora mukul against hyperglycemia and associated metabolic disorders in streptozotocin (STZ) induced diabetes in rats. The results showed that oral administration of GRE (40 mg/kg body weight) to diabetic rats effectively reduced the elevated plasma glucose and glycosylated hemoglobin (HbA1c ) levels and up-modulated the decrease in C-peptide and insulin levels compared to normal rats. The plant extract also successfully reduced the elevated plasma lipids including triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL-C) and modulated the decrease in the high density lipoprotein (HDL-C), and the associated hypertension in diabetic rats versus normal ones. The result also showed that the plant extract was effective in ameliorated plasma adeponectin of diabetic rats versus normal ones. Plasma homocysteine was lowered in diabetic animals compared to control ones, however, non significant change in its level was observed between diabetic animals and diabetic-GRE treated group. In conclusion, the present study proved that GRE has good glycemic control which may related to its antioxidant potential action, hence with its antioxidant activity, treatment with this plant extract can be effective in treatment of diabetes and associated disorders.
[Widad M. Al- Bishri and Omar S. Al-Attas. Guggul Resin Extract Improve hyperglycemia and Lipid Profile in Streptozotocin Induced Diabetes Mellitus in rats. Life Sci J 2013;10(1):2735-2741] (ISSN:1097-8135).http://www.lifesciencesite.com.
Keywords: Commiphora mukul, diabetes, metabolic disorders, adeponectin.