Identification for the Specific Depression-like Behavior of 60-Minute Maternal Deprivation Rats in Early Life
Mu-Hsin Chen1, Jen-Haur Lin1, Chih-Hung Lin1,*
1Department of Optometry, Chung-Hwa University of Medical Technology, Tainan City, Taiwan.
Abstract: In clinic, it is well known that maternal deprivation can lead to certain forms of depression. However, the evidence from basic researches on the relationship between maternal deprivation and depression is still inadequate, a major impediment in this research field is lack of validated animal models. In previous studies, most evidence showed that animals experienced maternal deprivation in early life would behave more anxiously, it means that maternal deprivation animals will form anxiety animal models. However, Just little evidence showed that maternal deprivation animals would express depression-like behavior. Therefore, it is so urgent to develop a steady and optimal maternal deprivation animal model for the research of depression. In this study, rats after parturition will submit to maternal deprivation process for 60 minutes a day from postnatal day 2 to 14. When the isolated rats wean, they will be separated from mother and raised independently. In addition to fundamental physiological condition measurements, 5-week-old maternal deprivation rats will proceed to forced swim test, spontaneous motor activity test, antidepressant treatments and active avoidance test. However, the results show that maternal deprivation rats experiencing all the tests will express depression-like behavior, but not anxiety-like behavior. Therefore, we find a novel depression animal model due to rats experiencing maternal deprivation for 60 minutes daily in early life. It is expected to offer more beneficial contributions to basic medical studies on the relations between maternal deprivation and depression by this animal model.
[Mu-Hsin Chen, Jen-Haur Lin, Chih-Hung Lin. Identification for the Specific Depression-like Behavior of 60-Minute Maternal Deprivation Rats in Early Life. Life Sci J 2012;9(1):548-553] (ISSN:1097-8135). http://www.lifesciencesite.com.82
Keywords: Maternal Deprivation, Depression, Forced Swim Test, Antidepressants, Active Avoidance Test Full Text 82