Oxidative stress biomarkers versus Magnetic Resonance Imaging (MRI) assessment in patients with tempromandibular disorders
Ahmed M Fleifel 1 and Yaser M. AlKhiary 2
1 MSc. Pharmacology and Experimental Therapeutics, Medical Research Institute, Alexandria University, Egypt
2Associate Professor of prosthodontics,, King Abdulaziz University, Faculty of Dentistry. Jeddah, Saudi Arabia.
Abstract: TMJ pain is a significant part of the symptoms in patients with TMJ disorders and a common source of orofacial pain. Interests in the recognition and management of TMD have increased dramatically in the past few years. Mechanical stresses are generated during functional or parafunctional movements of the jaw, adaptive mechanisms of the TMJ may be exceeded by free radical accumulation leading to a dysfunctional state. Ten patients selected with symptoms of TMJ pain, joint noises, limitation of jaw opening, tenderness located in the articular region and six healthy volunteers served as controls. Patients had full or nearly full complement of natural teeth. Clinical and radiographic (MRI) examination was done to determine disc displacement and success of treatment. Arthrocentesis (lavage) TMJ of TMD patients was carried out. Oxidative stress biomarkers of SOD, MDA and GSH of synovial fluid of TMD patients was measured. Our results revealed the success rate of improvement of sign and symptoms of joint tenderness,clicking and the range of mandibular movement before and after arthrocentesis. Oxidative stress of SOD and MDA was elevated while GSH was diminished. Based on these results we concluded that Oxidative stress are linked in the pathogenesis of the temporomandibular joint disorders. The antioxidant agents might be considered in management of TMJ pain and dysfunction to prevent possible increased oxidative stress.
[Ahmed M Fleifel and Yaser M.Al Khiary. Oxidative stress biomarkers versus Magnetic Resonance Imaging (MRI) assessment in patients with tempromandibular disorders. J Am Sci 2013;9(6):649-655]. (ISSN: 1545-1003).http://www.jofamericanscience.org. 83
Key Words: oxidative stress, synovial fluid,tempromandibular disorders, magnetic resonance image. Full Text 83