Panax Ginseng Extract Ameliorates Disturbed Lipid Metabolism and Associated Thyroid Hormones in Sera of Alloxan-Induced Diabetic Rats
Sahar M. Mahmoud1, Diaa B. Al-Azhary2 and Ahmed E. Abdel Moneim3
1Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt
2Department of Zoology, Faculty of Science, Minia University, Minia, Egypt
3Department of Zoology and Entomology, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt
Abstract: Diabetes mellitus is known to impair many physiological functions. Some reports claim that medicinal plants can reduce these alterations caused by Diabetes mellitus. The aim of this study was to investigate the effect of Panax ginseng extract (PGE), which is one of the most popular herbal remedies, on lipid profile and associated thyroid hormones in alloxan-induced diabetes in adult male albino rats. Animals were divided as follows: Control group (n=18), received 2ml of normal physiological saline solution (0.9% NaCl) for twenty one consecutive days. Alloxan monohydrate (ALX) group, (n=18); overnight fasted animals were made diabetic by a single subcutaneous (s.c.) injection of ALX (120mg/kg b.wt.) freshly prepared in 0.9% NaCl. Panax ginsengextract (PGE) group (n=18), animals were received a daily oral administration of (100mg/kg b.wt.) for 21 consecutive days. ALX & PGE group (n=18), animals were made diabetic by a single s.c. injection of ALX as shown in the 2nd group followed after one hour with oral administration of PGE as mentioned in the 3rd group, administration of PGE continued for 21consecutive days. All treated groups were decapitated at 7th, 14th and 21st days of treatment. Total lipids (TL), total triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triiodothyronine (T3), tetraiodothyronine (thyroxine,T4) and thyroid stimulating hormone (TSH) were assessed in blood sera of all treated groups. ALX-treated rats group revealed a significant elevation in TL, TG, TC and LDL-C, while indicating significant decreases in HDL-C, T3, T4 and TSH levels at all time intervals of the experiment. PGE administration to ALX-induced diabetic rats reversed the observed changes in the previously mentioned parameters as compared to ALX- treated group. Results of the present study indicate the ability of PGE to ameliorate the disturbed lipid metabolism and the involvement of thyroid hormones in counteracting ALX-induced diabetes in adult male albino rats.
[Sahar M. Mahmoud, Diaa B. Al-Azhary and Ahmed E. Abdel Moneim. Panax Ginseng Extract Ameliorates Disturbed Lipid Metabolism and Associated Thyroid Hormones in Sera of Alloxan-Induced Diabetic Rats.Life Sci J 2013;10(1):1136-1143] (ISSN:1097-8135). http://www.lifesciencesite.com.
Keywords: Panax ginseng, Diabetes, Lipid Profile, T3, T4, TSH, Rats.