The effect on vascular endothelial growth factor and C-reactive protein levels before and after coronary intervention treatment of coronary heart disease
Ya Li, Zesheng Xu, Yongxing Liu, Wanzhong Peng
Department of Cardiology, Hebei Cangzhou Central Hospital, Hebei 061001, China
Abstract: Objective: To investigate the changes in the vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) levels before and after percutaneous coronary intervention treatment. Methods: 87 cases of coronary heart disease were treated with percutaneous transluminal coronary angioplasty (PTCA) and stent implantation in The Central Hospital of Cangzhou, Hebei Province from March 2011 to November 2012. CRP and VEGF changes were determined during the interventional Therapy. Results: Among 102 patients, the group of 87 patients with a total placement stent, two cases of double vessel disease in patients with descending artery stenosis, no-reflow phenomenon in 2 patients which abandoned PTCA guidewire , the surgical success rate was 95.4% (83 / 87). CRP and VEGF levels stent implantation done immediately after than before surgery (P <0.05), and 24 hours at peak below preoperative levels after one month, the difference was statistically significant (P <0.05). Conclusion: PTCA compared with preoperative CRP and VEGF levels increased, its variation may reflect the severity of coronary lesions and the degree of myocardial ischemia, monitoring of serum CRP and VEGF can understand the extent of the clinical therapeutic effects and inflammatory lesions.
[Ya Li, Zesheng Xu, Yongxing Liu, Wanzhong Peng. The effect on vascular endothelial growth factor and C-reactive protein levels before and after coronary intervention treatment of coronary heart disease. Life Sci J2013:10(1):3177-3179]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
Key words: coronary heart disease; intervention; vascular endothelial growth factor; C-reactive protein.