Echocardiographic Evaluation of Cardiac Structural and Functional Changes in Hepatitis C Positive Non-Alcoholic Liver Cirrhosis Patients and Their Plasma NT-ProBNP Levels
Manal Eldeeb1, Ragai M. F. R. Fouda1, Mona M.R. Hammady1 and Laila Rashed2
1Internal Medicine Department Cairo University, 2Biochemistry Department Cairo University
Abstract: Background: Cirrhotic cardiomyopathy (CC) refers to cardiac structural, functional, and electrophysiological changes in liver cirrhosis (LC) patients. Emerging role of natruretic peptides in screening LC patients for development of CC was suggested. The aim of this study was to assess structural and functional cardiac changes in hepatitis C positive nonalcoholic (LC) patients and N- terminal pro brain natriuretic peptides (NT-proBNP) blood levels in these patients.Methods: Forty hepatitis C positive LC patients classified according to their child - Pugh score underwent transthorathic echocardiographic assessment of cardiac chambers dimensions, and left ventricular functions. Estimation of plasma NT-proBNP levels of these patients and 10 healthy age and gender matched healthy control subjects was done. Results:Child-Pugh C LC patients have significantly higher mean left ventricular end diastolic (LVEDD) and end systolic dimensions (LVESD) compared to those of Child- Pugh A and B LC patients. LV systolic function was preserved in the three Child- Pugh groups, while diastolic dysfunction was detected in 78.5% of Child- Pugh C patients. Mean plasma NT-proBNP level was significantly higher in Child-Pugh C patients compared to mean plasma levels in Child- Pugh A and B patients. ProBNP plasma levels correlated significantly with serum albumin, bilirubin, creatinine, international normalized ratio, Child-Pugh score, LVESD, LVEDD, left atrial and right ventricular diameters. Conclusion: Child-Pugh C LC patients suffered of cardiac structural changes associated with diastolic dysfunction and raised mean ProBNP plasma level but preserved systolic function. NT-ProBNP levels correlated significantly with echocardiographic changes and Child- Pugh score.
[Manal Eldeeb, Ragai M. F. R. Fouda, Mona M.R. Hammady and Laila Rashed. Echocardiographic Evaluation of Cardiac Structural and Functional Changes in Hepatitis C Positive Non-Alcoholic Liver Cirrhosis Patients and Their PlasmaNT-Probnp Levels. Life Sci J 2012;9(1):786-792]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 113
Key words: cirrhosis- cardiomyopathy-echocardiography- NT-proBNP-Hepatitis Full Text 113