1-Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran (Correspondences Author, email@example.com)
3. Department of Pathology, Rasht Branch, Islamic Azad University, Rasht, Iran
Abstract: PCOS produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility. To confirm the role of nutrition with omega-3 polyunsaturated fatty acid on controlled of experimental PCO induced by estradiol-valerat (PPA) in rats, this study was done. Wistar female rat (n=50) were allocated into control (n=10) and test groups (n=40), test group subdivided into groups of 4, G1, received omega-3 (60 mg/rat/orally/daily),G2 induced PCO by single injection of estradiol-valerate (4mg/rat/IM), G3 and G4 groups were induced PCO by single injection of estradiol-valerate (4mg/rat/IM),G3 & G4 groups was received omega-3 (60 mg/rat) ,and G4, received lower carbohydrate feeding ,for 60 consequence day. In sixty day 5cc blood samples and ovarian tissues of Rats in whole groups were removed and prepared to biochemical pathological analysis. hemorrhage, hyperemia and fibrosis were seen in pco groups, these side effects in groups that received omega-3 and lower carbohydrate feeding, significantly decreased (p<0.05) in comparison to experiment groups and ovarian weights in both experimental and control group were similar(p<0.05). Results revealed that administration of omega-3 plus lower carbohydrate food significantly controlled PCO syndrome.
[Elaheh Ouladsahebmadarek, Arash Khaki, Laya Farzadi, Afshin Zahedi. Nutrition with polyunsaturated fatty acid and lower carbohydrate diet has controlled poly cystic ovarian syndrome, on poly cystic ovarian (PCO) induces rats. Life Sci J 2013;10(1):1171-1175] (ISSN: 1097-8135). http://www.lifesciencesite.com.
Key words: Carbohydrate, Omega-3, Nutrition, Ovary, PCO.