Antibodies to Cyclic Citrullinated Peptides (Anti-CCP) as a Marker of Association between Type 1 Diabetes Mellitus (T1DM) and Rheumatoid Arthritis (RA) in Children and Adolescent
Doaa Shahin 1, Rawia A. Swelam2, Abeer Fathy 3, Dina A. Shahin4*, Mohamed Attiya5
1. Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
2. Department of Pediatric, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
3. Department of Pediatric, Faculty of Medicine,, Mansoura University , Mansoura , Egypt .
4. Department of Internal Medicine, Rheumatology and Immunolology unit, Faculty of Medicine, Mansoura University, Mansoura , Egypt.
5. Department of Internal medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract: Aims/Introduction: The association between Type 1 diabetes mellitus (T1DM) and rheumatoid arthritis (RA) remains controversial. The aim of this work was to find out the prevalence of anti-CCP in children and adolescences with T 1 DM and to determine whether anti-CCP could serve as marker for the development of RA in these patients. Material and Methods: We studied 42 children and adolescents with T1DM, 20 patients with RA, and 40 healthy age and sex matched controls. The studied groups were investigated for anti-CCP and RF and the result were statistically analyzed. Results: The number of anti-CCP positive patients in the diabetic group was not statistically different when compared with the healthy control group (1 vs. 0, P = 1) but was statistically lower than in the RA group (1 vs. 9, P< 0.0001). Family history of RA was detected in only two of the diabetic patients with no significant difference than the control group. Family history of first degree relative with type 1 DM was not statistically significant different between the RA group and the control population (p= 0.4). Conclusions: No significant difference in anti-CCP antibodies expression in patients with T1DM than the healthy control. Screening of anti-CCP antibodies may not appear to be useful in the follow-up of patients with type 1DM unless there are joint abnormalities.
[Doaa Shahin, Rawia A. Swelam, Abeer Fathy, Dina A. Shahin and Mohamed Attiya. Antibodies to Cyclic Citrullinated Peptides (Anti-CCP) as a Marker of Association between Type 1 Diabetes Mellitus (T1DM) and Rheumatoid Arthritis (RA) in Children and Adolescent. Life Sci J 2013;10(1):3061-3065]. (ISSN: 1097-8135).http://www.lifesciencesite.com. 8
Key words: anti-CCP, Type 1 diabetes mellitus, rheumatoid arthritis.