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Experimental study on the expression of VEGF and BMP-2 in steroid-induced osteonecrosis of the femoral head
Sun Naikun Rui Gang, Liu Fu-Ann
First Affiliated Hospital of Xiamen University, orthopedics, Xiamen 361003
Abstract: Objective: To study the expression and significance of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) gene in steroid-induced osteonecrosis of femoral head. Methods:30 healthy adult New Zealand white rabbits are randomly divided into model group (20) and control group(10), the model group will be used to make necrosis model of femoral head, by the aid of methods including immunohistochemistry and ELlSA, we can study the changes and characteristics of VEGF and BMP-2 gene, thus comparing with the control group. Results: in the 8th week, the VEGF and BMP-2 gene expression level in the femoral head of the model group is lower than the control group, so is the expression intensity of gene positive, area percent and vacant osseous lacuna percentage, in this sense, the difference is of statistical significance(P<0.05). Conclusion: In the produced exogenous necrosis model of rabbit femoral head, the VEGF and BMP-2 gene expression in the femoral head is restrained, which shows the VEGF and BMP-2 gene expression plays an important role in the pathogenesis of femoral head necrosis.
[Sun Naikun Rui Gang, Liu Fu-Ann. Experimental study on the expression of VEGF and BMP-2 in steroid-induced osteonecrosis of the femoral head. Life Sci J 2013;10(1):2853-2857] (ISSN:1097-8135).http://www.lifesciencesite.com.
Key words: steroid induced osteonecrosis of the femoral head; rabbit; model; vascular endothelial growth factor; bone morphogenetic protei.