Role of Pr
Role of Pregabaline in prevention of Oxaliplatine neuropathy.
Emad Sadaka1 and Alaa Maria2
Clinical Oncology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt.
Abstract: Background: Neuropathy occurs in most of patients receiving oxaliplatine. Many neuromedulatory drugs were tested in prevention and treatment of oxaliplatine induced neuropathy. The aim of this pilot study is to evaluate the role of pregabalin “PGB” (an antiepileptic drug approved as a treatment for neuropathy) in prevention of oxaliplatine induced acute neuropathy. Methods: Forty-seven patients with resected stage III and high risk stage II colon cancer were treated with FOLFOX4 protocol in 2 groups, the PGB group (23 patients) and the control group (24 patients) throughout the period From Jan. 2010 to Dec. 2011 at Clinical Oncology Department, Tanta University Hospital. Results: The PGB group showed lower incidence of all neurological grade of toxicity. After 2 cycle, Grade 1-2 toxicity presented in 21.7% and 45.8% for the PGB group and control group respectively (p=0.08). No patient showed grades 3-4 neurological toxicity in both groups. After 4 cycles, PGB group showed a significantly lower incidence of neurological toxicity, Grades 1-2 neurological toxicity presented in 34.8% vs. 62.5% for the control group and grade 3-4 in 4.3% vs. 16.7% respectively (p=0.02). After 6 cycles, PGB group maintained a significantly lower incidence of neurological toxicity (p=0.04). The need for oxaliplatine dose reduction was insignificantly lower in the PGB group 4.3% vs. 14.7% in the control group (p=0.2). Interference of daily activity was significantly lower in the PGB group than the control group (13% vs. 41.7% respectively; p=0.03). Patient in the PGB group showed a comparable DFS rate at 2 year with the control group (74.8% vs. 69.3% respectively, p=0.39). Conclusion: Pregabalin significantly reduced the oxaliplatine induced neuropathy without compromising survival.
[Emad Sadaka and Alaa Maria. Role of Pregabaline in prevention of Oxaliplatine neuropathy. J Am Sci2013;9(3):198-202]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 26
Keywords: Oxaliplatine, Neuropathy, Pregabalin. Full Text 26