Anesthetic Induction with Propofol versus Ketamine Pre and Post Lower Pole Nephrectomy in Dogs
Shekidef, M. H1.; Helal, I. E2 and Ramadan, Taha3
Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Suez Canal University1, Experimental Surgery Unit, King Fahd Medical Research Center, King Abdul Aziz University2& Department of Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University3.
Abstract: This study was performed on fourteen Mongrel dogs to compare anesthetic induction in healthy, as well as, partially nephrectomized dogs using bolus intravenous administration of either propofol 4 mg/kg b.wt.in group I (before nephrectomy) and group II (one month after lower pole nephrectomy) or ketamine 10 mg/kgb.wt. in group III (before nephrectomy) and group IV (one month after lower pole nephrectomy). The quality of induction and recovery, the occurrence of cardiovascular and respiratory side effects and serum biochemical parameters were investigated. The results revealed that, anesthetic induction time did not change significantly in dogs before and after nephrectomy under the effect of either propofol or ketamine. Meanwhile, ketamine induced significantly longer weak time and down time than did propofol in corresponding groups. RRF was significantly longer in nephrectomized than non nephrectomized dogs under the effect of both agents while, recovery time was significantly longer in nephrectomized than non nephrectomized dogs under the effect of propofol. Ketamine caused significantly longer recovery time than did propofol in corresponding groups. There were no significant differences in induction and recovery scores before and after nephrectomy in dogs anesthetized with either propofol or ketamine. However, propofol caused significantly better induction and recovery than did ketamine in corresponding groups. Propofol caused significant decrease but ketamine caused significant increase in heart rate and respiratory rate in both nephrectomized and non nephrectomized dogs. Meanwhile, they did not significantly alter rectal temperature. ECG tracings showed only change in heart rate without arrhythmias. Significant increases in AST, LDH, CPK, urea and creatinine were observed in all groups with minor disparity from one to another group. It could be concluded that ketamine had better cardiopulmonary effect than propofol but the later was superior in the quality of induction and recovery. Lower pole nephrectomy in dogs had minimal impact on the modality of the effect of either agent.
[Shekidef, M. H.;Helal, I. E. and Ramadan, Taha. Anesthetic Induction with Propofol versus Ketamine Pre and Post Lower Pole Nephrectomy in Dogs. Life Sci J 2013;10(1):3070-3080]. (ISSN: 1097-8135).http://www.lifesciencesite.com.
Key words: Dog – ketamine – nephrectomy - propofol.