Design, Formulation and Evaluation of Medicinal Chewing Gum by the Extract of Salvadora persica L.
Abolfazl Aslani1, Alireza Ghannadi2, Shiva Mortazavi3 and Marzieh Torabi4
1Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,
2Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran,
3Department of Pediatric Dentistry, School of Dentistry and Dental Research Center , Isfahan University of Medical Sciences,
4 School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
ABSTRACT: Dental caries is one of the common hygienic problems. Salvadora persica L. Or Miswak is rich in fluorine and many anti-bacterial agents. Fluoride helps to prevent dental caries. Chewing gum as a preparation to prevent tooth decay and improve oral health can be supplied to the pharmaceutical market. This study aimed to evaluate the organoleptic, physicochemical and mechanical characteristics of the gum, the product designed to provide the consumer's optimal. The plant was prepared from Hormozgan State. Its stems and twigs were ground; then percolated at 25° C. Liquid glucose, glycerin, various sweeteners, plant extracts and flavorings have been added to the softened gum base at the proper temperature. In order to evaluate the organoleptic characteristics of the product, Latin square was designed. Weight variation and content uniformity were determined. Fluoride release has been studied by means of the mechanical chewing device in phosphate buffer with the pH adjusted at 6.8. The mechanical properties of the product were evaluated by using a tensile testing machine. The amount of fluoride per gram of extract was 0.111 ± 0.017 µg. Organoleptic properties were evaluated at 3 stages in the volunteers. The average weight of the chewing gum for F11 to F15 was 832.0 ± 2.9, 829.0 ± 2.2, 833.3 ± 3.9, 829.2 ± 3.2 and 828.0 ± 3.8 mg respectively. The mean amount of fluoride in the gums form F11 to F15 was 94.1 ± 5.7%, 92.3 ± 5.7%, 96.5 ± 4.7%, 93.9 ± 4.4% and 95.6 ± 3.8% of the claim respectively. F11 to F15 after 15 minutes released 62%, 73%, 80%, 69%, 73%, and finally 85%, 92%, 97%, 94%, 95% of their fluoride in the release medium respectively. The mechanical testing was performed. Parameters such as yield strength, ultimate strength, toughness, elongation, and modulus of elasticity are calculated. In this study S. persica L. is extracted and formulated into chewing gum with favorable taste and suitable organoleptic properties as F12. The best sweetener for persica gum is xylitol and peppermint is the best flavoring agent. It is succeeded in the content uniformity, release and mechanical tests.
[Abolfazl Aslani, Alireza Ghannadi, Shiva Mortazavi and Marzieh Torabi. Design, Formulation and Evaluation of Medicinal Chewing Gum by the Extract of Salvadora persica L.. Life Sci J 2013;10(4s):47-55] (ISSN: 1097-8135).http://www.lifesciencesite.com. 7
Key Words: Medicated chewing gum, dental caries, fluoride, oral health, Salvadora persica L., fluoride ion selective electrode, tensile test.