Effect of Br
Effect of Breast-feeding and Formula- feeding on Antibody Response of Hepatitis B Vaccination
Mohsenzadeh A1, Ahmadipour SH1 , Firouzi M1, Babaei Homa2 , Anbari KH3
1-Department of Pediatrics, Shahid Madani Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.
2-Department of Pediatrics, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3-Community medicine specialist, Lorestan University of Medical Sciences, Khorram Abad, Iran.
Corresponding Author: Ahmadipour Shokoufeh, Email: firstname.lastname@example.org
Abstract: Background and aim: About one-third of the world's population has some serologic evidence of suffering infection by hepatitis B virus (HBV). One of the effective measures for reducing the mortality because of hepatitis B virus is vaccination at birth time, 2 months and 4 months old. The criterion for effectiveness of hepatitis B vaccine is enough production of antibody. The aim of this study is to investigate the immunity response to hepatitis B vaccination in breast-fed and formula-fed infants vaccinated at the age of 12-24 months. Material and methods: This descriptive study is conducted using accessible sampling based on entrance criteria on healthy 12-24 months old infants who received 3 dose of hepatitis B vaccine. one group was 51 formula-fed infants and the other 56 breastfed infants. Blood sample was taken from both groups to measure the antibody titer of hepatitis B using ELISA experimental method, and finally both groups were compared based on their antibody level and age, sex and the type of feeding. Results: Both groups were the same with regard to age average and sex. Overall 9 infants (8.4%) had antibody titer of lower than 10 mIU/ml and didn't response well to vaccine, among whom 1 was breast-fed and 8 ones were formula-fed infants. HBS-Ab average was 124.4±55.9 mIU/ml and 91.7±51.1mIU/ml in the first and second group respectively (p=0.002).The response in the first group (98.2%) had a meaningful difference with the second group (84.3%) (p=0.009). In each group, there was no significant statistical difference between girls and boys in responding the vaccine, but in both groups overall, the boys had more immune response to hepatitis B vaccine compared to girls (p=0.004). Conclusion: The results of this study showed that breastfed infants respond well to hepatitis B vaccine and the average antibody titer is higher in boys.
[Mohsenzadeh A, Ahmadipour SH, Firouzi M, Babaei Homa, Anbari KH. Effect of Breast-feeding and Formula- feeding on Antibody Response of Hepatitis B Vaccination. Life Sci J 2013;10(1):2063-2068] (ISSN:1097-8135).http://www.lifesciencesite.com.
Keywords: Hepatitis B; Antibody; Breastfeeding; Formula.