Study of sed
1- Department of Clinical Science, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2- Department of Microbiology, Ahar Branch, Islamic Azad University, Ahar, Iran
* Corresponding Author’s Email: firstname.lastname@example.org
Abstract: The genus Achillea comprises of ∼85 species, most of which are endemic to Europe and the Middle East. Turkish flora possesses 42 Achillea species and 23 of them are endemic. The aim of this study was to investigation of the sedation, pre-anesthetic and anti-anxiety effects of polar, semi-polar and non-polar fractions of yarrow (Achillea millefolium) extract compared with diazepam in rats. In the present study, 90 wistar male rats were numbered in groups consisted of 15 animals and were placed in especial cages. In order to evaluate the sedation and pre-anesthetic effects of yarrow extract compared with diazepam, 100 mg/kg of polar extract in first group, 100 mg/kg of semi-polar extract in second group, 100 mg/kg of non-polar extract in third group, 2 mg/kg diazepam in group four, 2 mg/kg amount of dimethyl sulfoxide was injected intra peritoneal in fifth group, and sixth group did not receive any drug. Elevated plus maze was used in order to evaluate anti-anxiety effects of yarrow extract. The results of dual Tokay follow up test show a significant difference between intra peritoneal injections of 100 mg/kg BW of polar extract than semi-polar and non-polar than diazepam. Intraperitoneal injection of polar fraction of yarrow extract has showed better and significant effects than semi-polar, non-polar and diazepam. In conclusion, can state that, polar-fraction of yarrow has more sufficient sedative, pre-anesthetic and anti-anxiety effects than diazepam and other under studied groups. Authors suggest that still need more studies on this plant component in order to understand the more sedative and anxiolytic effects of this plant.
[Ali Rezaie, Changhiz Ahmadizadeh. Study of sedation, pre-anesthetic and anti-anxiety effects of polar, semi-polar and non-polar fractions of yarrow (Achillea millefolium) extract compared with Diazepam in rats. Life Sci J 2013; 10(1):907-913] (ISSN: 1097-8135). http://www.lifesciencesite.com.
Keywords: Yarrow, Sedation, Anti-Anxiety, Polar, Semi-Polar, Non-Polar Fraction, Dimethylsulfoxide, Rat.