Combination of Trimethoprim - Sulfa methoxazole (Tr-SMZ) and Triplennamine (Trip) Induced QT Prolongation in Cattle
Mohammad mashayekhi1*, Mohammad Amin Shahbazi2, Mohsen Ahmadi Roozbahani3
1. Department of Clinical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2. Young Researchers club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3. Department of Veterinary, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Corresponding author: TEL: +989144126030, Email address: Mashayekhi@iaut.ac.ir (Mohammad Mashayekhi)
Abstract: Trimethoprim (Tr) in combination with Sulfa methoxazole (SMZ) has a wide spectrum of activity against gram positive and negative organism. Although the popularity of using this drug because of its ease of administration noticeably has increased, numerous side effects of these drugs have been reported. Some of the most important of them are included: The skins, hematopoietic system, gastrointestinal tract, kidney and cardiotoxicity. Antihistamines are another cardio toxicity drugs that widely are prescribed in the world for treatment of allergic diseases. Histamines cause a series of action upon the cardiovascular system such as ventricular arrhythmia and QT prolongation by blocking rectifier potassium (k+) channels. However, co-administration of this drug with Tr-SMZ has become very popular for minor reasons in cattle. Unfortunately, there is no reliable source about cardio toxicity of these in QT prolongation. So the aim of this study was to assess the effects of Tr-SMZ with Trip on electrocardiographic criteria in Holstein cows.
[Mohammad mashayekhi, Mohammad Amin Shahbazi, Mohsen Ahmadi Roozbahani. Combination of Trimethoprim - Sulfa methoxazole (Tr-SMZ) and Triplennamine (Trip) Induced QT Prolongation in Cattle. Life Sci J 2013;10(4s):128-131] (ISSN: 1097-8135). http://www.lifesciencesite.com. 19
Key words: QT prolongation, Torsade De Pointes, Trimethoprim-Sulfamethoxazole, Triplennamine.