Correlation between levels of serum homocystein, high sensitivity C-reactive protein and subtypes of large-artery atherosclerosis ischemic stroke
Ping Zhang1，Zhen Huang1, Yongkun Gui1, Bin Zhu1,Xiaolu Niu1, Haiqing Yan1,
Xuejing Yue1, Tong Li1， Yuming Xu2
1Department of Neruology ,the First Hospital afflicated to XinXing Medical Universit, Xinxiang, Henan 453003, China.
2Department of of Neurology, First Affiliated Hospital to Zhengzhou University, Zhengzhou, Henan 450003, China.
【Abstract】: Objective To investigate the levels of serum homocystein ( Hcy) and high sensitivity C-reactive protein (hs-CRP) and their differences in each subtype of artery atherosclerosis ischemic stroke. Methods: All ACI patients were classified into large-artery atherosclerosis (n = 130) and small-vessel occlusion (n = 87) based on TOAST. The groups of large-artery atherosclerosis included progressive stroke (PS) (n=58) and complete stroke (n=72). Another group was also divided into PS (n=12) and complete stroke(n=75). Levels ofserum Hcy and hs-CRP concent were measured and compared between groups. Results: (1) The levels of HCY and hs-CRP in large-artery atherosclerosis group were higher than in small-vessel occlusion group; (2) The levels of HCY and hs-CRP were higher in PS than in complete stroke in two groups; (3) There was nosignificant difference of the levels of HCY between PS and complete stroke in large-artery atherosclerosis,while the levels of hs-CRP were higher in PS. Conclusions: Levels of serum Hcy and hs-CRP were related to the occurrence of large-artery closely,which may be regarded as an index to predict and evaluate the large-artery atherosclerosis. Hyperhomocysteinemia didn’t indicate the PS.
[Ping Zhang, Zhen Huang, Yongkun Gui, Bin Zhu, Haiqing Yan, Xiaolu Niu, Xuejing Yue, Tong Li, Yuming Xu. Correlation between levels of serum homocystein, high sensitivity C-reactive protein and subtypes of large-artery atherosclerosis ischemic stroke. Life Sci J 2013;10(1):3145-3149] (ISSN:1097-8135).http://www.lifesciencesite.com.
Key words: Ischemic stroke; large-artery atherosclerosis; High-sensitivity C-reactive protein; Homocysteine