Chronic Intake of Iodized Retail Table Salt(S) As Reflected On Thyroid Function and Certain Metabolic Aspects in Experimental Rats
Mohamed M. El-Seweidy 1 and Omnia Ezzat 2
1 Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig,
2 Biochemistry Department, Faculty of Pharmacy, Egyptian Russian University
Abstract: Effective salt iodization is a prerequisite measure to combat disorders of iodine deficiency. However, it appears that the problem still exists. Iodized table salts (fine and coarse retailed forms) which are available in the Egyptian market were selected to test their effect, according to their iodization level. Male albino rats were used, divided into four groups and received oral salt solutions in different concentration levels for 90 days as follows; group I: served as control and received no salt solution, group II: referred to low iodine dose, group III: as moderate iodine dose, group IV: expressed as high iodine dose. Body weights were recorded and blood samples were collected, at the start of the study and at 1 month interval for 3 successive months’ and processed for determination of thyroid hormones, mainly plasma free T3, fT4, TSH, fructosamine, insulin, and qualitative C-reactive protein (CRP), being followed by histological examination of thyroid tissues. Salt intake of different iodine concentrations induced significant increase in TSH, fT4, and CRP. However, fT3, fructosamine, and insulin demonstrated significant decrease.
[Mohamed M. El-Seweidy and Omnia Ezzat. Chronic Intake of Iodized Retail Table Salt(S) As Reflected On Thyroid Function and Certain Metabolic Aspects in Experimental Rats. Life Sci J 20132;10(1):3342-3348]. (ISSN: 1097-8135). http://www.lifesciencesite.com
Key words Retail iodized table salt, fT3, fT4, TSH, Fructosamine, Insulin, CRP.