Effect of Alli
Laya Farzadi1, Arash Khaki¬2, Alia Ghasemzadeh1, Zahra Bahrami Asl1, Sharareh Khan ahamadi1, Hamidreza Ahmadi Ashteani3
1-Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3-Department of Biochemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
*Corresponding Author: Arash Khaki, firstname.lastname@example.org
Abstract: Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility, affecting about 5–10% of women in age of procreation. See antioxidants effects of Allium cepa seeds ethanol extract on experimental PCO induced by estradiol-valerat (PPA) in rats. Wistar female rat (n=60) were allocated into three groups, control (n=30), C1: an equal volume of (0.9% NaCl); C2: extract (0.3cc/rat/orally/daily); C3: Sesame oil(0.3cc/rat/orally/daily) and test groups (n=30), that subdivided into groups of 3,one group received extract supplement (0.3cc Sesame oil+ 0.3cc Allium Cepa /rat/orally/daily), second and third groups were induced PCO by single injection of estradiol-valerate (4mg/rat/IM),third group, was received extract supplement, for 60 consequence days. Animals were kept in standard conditions. In last day of study the blood samples of rats in whole groups were removed and prepared to biochemical analysis. level of TAC, Superoxide dismutase and catalase were significantly decreased in pco groups (p<0.05), these side effects in groups that received extract significantly increased (p<0.05) in comparison to control and PCO groups and level of MDA in PCO groups were significantly increased as compared to control and extract groups (p<0.05). Results revealed that administration of Allium cepa ethanol extract significantly compensation blood antioxidants level in PCO induces rats.
[Laya Farzadi, Arash Khaki, Alia Ghasemzadeh, Zahra Bahrami Asl, Sharareh Khan ahamadi, Hamidreza Ahmadi Ashteani. Effect of Allium Cepa seeds Ethanolic Extract, on Serum Total Antioxidant in Experimental induced Poly cystic ovarian (PCO) rats. Life Sci J 2013;10(4s):97-102] (ISSN: 1097-8135). http://www.lifesciencesite.com. 14
Key words: Allium cepa extract, sesame oil, Superoxide dismutase, MDA, PCO, Catalase, TAC.