1. Department of Forensic Pathology, Xinxiang Medical University; 2. Department of Pathology, Xinxiang Medical University; 3. Third Teaching Hospital of Xinxiang Medical University, Xinxiang, 453003, China; 4. The first people’s hospital of Zhengzhou.
Abstract AIM: To detect the expression of Nuclear transcription factor-kB(NF-κB) and vascular endothelial growth factor-C(VEGF-C) protein in esophageal squamous cell carcinoma (ESCC) and explore their relationship with the prognosis of ESCC. Methods: SP immunohistochemical method was used to detect the expression of NF-κB and VEGF-C protein in 124 cases of ESCC and 62 cases of normal esophageal mucosa. Results: The positive expression rates of NF-κB and VEGF-C protein in specimens of ESCC were 53.2% and 69.4%, in normal esophageal mucosa were 17.7% and 3.2%, respectively. Both of them had the significant differences between ESCC and normal mucosa (P < 0.05). The positive expression of NF-κB and VEGF-C protein were closely correlated with the infiltration and lymph node metastasis of ESCC (P < 0.05), but were not correlated with the tumor grade, age or gender of the patients (P > 0.05). Moreover, the expression of NF-κB protein was positively correlated with VEGF-C (P<0.05). Conclusion: The expression of NF-κB and VEGF-C protein is closely correlated with the clinic pathological characteristics of ESCC. The genes of NF-κB and VEGF-C may play important roles in the infiltration and metastasis ESCC. United detection of them may be used as important prognostic predictors in ESCC.
[Zheng Tang , Yongxia Wang , Aihong Yang, Xinlai Qian Yu Wang. Expression and clinical significance of NF-κB and VEGF-C in esophageal squamous cell carcinoma. Life Sci J 2013;10(1):3044-3047] (ISSN:1097-8135).http://www.lifesciencesite.com.
Key words: esophageal squamous cell carcinoma; nuclear transcription factor-κB; vascular endothelial growth factor-C; invasion; metastasis; prognosis.