Anti-Inflammatory and Immune Regulatory Effects of Salvia officinalis Extract on OVA-induced Asthma in Mice
Abd El-Hamid Mohamed Elwy1 and GhadaTabl2
1 Forensic Medicine and Toxicology Department, Faculty of Medicine, Tanta University
2 Zoology Department, Faculty of Science, Tanta University
Abstract: The study designed to evaluate the protective effect of Salvia officinalis (SO) water extract against OVA- induced asthma in mice. The OVA-induced asthmatic mice exhibited significant increase in total leukocytes count, IL-4 and IL-5 levels in bronchoalveolar lavage fluid (BALF) and eosinophils count in (BALF), in addition, to the serum total IgE level. Pathological changes in the lung were evaluated and compared to either treated OVA-challenged SO group or control- Salvia Officinalis oral administered group.Salvia Officinalis extract reduced significantly the number of inflammatory cells and cytokines in the BALF and the level of IgE as compared to OVA-challenged group. Moreover, Salvia Officinalis extract (SO) reduced the eosinophils infiltration in the lung tissue. These results suggest that Salvia officinalis extract via oral treatment may have anti-inflammatory and immune regulatory effects on bronchial allergic asthma.
[Abd El-Hamid Mohamed Elwy and GhadaTabl. Anti-Inflammatory and Immune Regulatory Effects of Salvia officinalis Extract on OVA-induced Asthma in Mice. Life Sci J 2013;10(1):1874-1878] (ISSN:1097-8135).http://www.lifesciencesite.com.
Keywords: Salvia officinalis extract- OVA-induced asthma-Leukocytes-Cytokines- Eosinophils-Serum IgE level.