Biochemical and Histological Studies on the effect of Zearalenone Mycotoxin and Thymoquinone on Male Mice Kidney
Nagwa Mohammed EL-Sawi1, Madeha Nooh Al-Seeni 2, Sabry H. H. Younes1, Salma Mohammed AL-Jahdali2, and Soad Shaker Ali3
1Chemistry Dept, Faculty of Science, Sohag University, Egypt.
2Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
3Histology, Medicine Faculty King Abdulaziz University, Jeddah, Saudi Arabia
Abstract: ZEN was evaluated in male adult mice; given single and repeated doses of ZEN (2.7 mg/kg B.W). Also effect of Thymoquinone extracted from Nigella Sativa was assessed. Mice were divided into 4 groups. G1: receiving toxin once and dissected 48 hrs later, G2: given toxin twice a week for one week, G3: given toxin twice a week for 2 weeks, G4: pretreated o rally by Thymoquinone (10 mg/Kg B.W) for 7 days prior to administration of ZEN twice a week for two weeks. Blood serum urea nitrogen creatinine, alpha-fetoprotein, pyruvate kinase isoenzyme tumor M2 and total antioxidant status was assessed. All groups compared to control. The recovery occurred in TQ group based on changes in level of all groups when comparing with G3. Histological changes of mice kidney coincided with biochemical changes.
[Nagwa Mohammed EL-Sawi, Madeha Nooh Al-Seeni, Sabry H. H. Younes, Salma Mohammed AL-Jahdali, and Soad Shaker Ali. Biochemical and Histological Studies on the effect of Zearalenone Mycotoxin and Thymoquinone on Male Mice Kidney. J Am Sci 2012;8(10):378-388]. (ISSN: 1545-1003).http://www.jofamericanscience.org. 56
Keywords: Mycotoxins, Zearalenonen, Nephrotoxicity, Nigella Sativa, Thymoquinone. Full Text 56