Pro- and anti-i
Pro- and anti-inflammatory cytokines in uncomplicated type 2 diabetes patients
Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. email@example.com
Abstract: Background. Role of systemic pro- and anti-inflammatory cytokines are associated with type 2 diabetes mellitus (T2DM) in adults is unclear. In this cross section study, we compared cytokine concentrations in patients with T2DM and healthy individuals to test the hypothesis that differences of cytokine concentrations between them are attributable to diabetes and metabolic control. Methods. The pro-inflammatory cytokine as interferon gamma (IFN-γ) and anti-inflammatory cytokines as adiponectin and interleukin (IL)-10 were measured in 50 participants with T2DM and 70 healthy controls using ELISA kits. Results. IFN-γ was significantly increased while adiponectin and IL-10 were significantly decreased in T2DM than healthy controls (P <0.0001). In T2DM patients, negative correlations were found between fasting blood glucose with adiponectin (r= -0.293, P <0.039) and IFN-γ with IL-10 (r= -0.320, P <0.023). BMI was positively correlated with IFN-γ (r= 0.723, P <0.0001) and glycozylated hemoglobin (r=0.399, P<0.016). Conclusion. T2DM showed elevated serum levels of inflammatory cytokine IFN-γ and decrease serum levels of anti-inflammatory cytokines (adiponectin and IL-10) and negative association between anti-inflammatory cytokine and blood glucose levels indicated importance of inflammation in pathogenesis of T2DM. The hypothesis that T2DM is inflammatory disease opens new clinical perspectives for diagnosis and treatment but still requires further investigation.
[Laila Damanhouri. Pro- and anti-inflammatory cytokines in uncomplicated type 2 diabetes patients. J Am Sci 2012;8(10):466-472]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 68
Keywords: Adiponectin. Glycozylated hemoglobin. Interleukin-10. Interferon gamma. Type 2 diabetes in adult. Full Text 68