Alfa-Fetoprotein L3 Subfraction and Osteopontin: Novel Markers for the Diagnosis of Hepatocellular Carcinoma
Sawsan Said Hafez1, Aziza Ahmed El Sebai1, Manal Mohamed Abd AL Aziz1 Manal Abdel Baky Mahmoud1, Mohamed Omar El Maraghy1, Mohamed Omar Khalifa 2 and Nevine Ibrahim Musa3
Departments of Clinical Pathology1, Tropical Medicine2 and Internal Medicine3, Faculty of Medicine, Ain Shams University. firstname.lastname@example.org
Abstract: Objective: This study was designed to evaluate the role of serum alpha-fetoprotein-L3 subfraction (AFP-L3) and osteopontin (OPN) in the diagnosis of hepatocellular (HCC) and to consider their potential role as a novel prognostic marker. Patients and Methods: 120 patients with different stages of HCC were included in addition to 140 subjects with chronic liver diseases and 140 healthy control. Following clinical and radiological investigations, serum assay of AFP, AFP-L3 and OPN were performed.Results: AFP, AFP-L3 and OPN were significantly higher in HCC patients compared to chronic liver disease patients and normal control. A significant correlation was found between AFP and AFP-L3/AFP ratio among HCC patients. OPN varied significantly among different HCC stages. The best cutoff points revealed 100% sensitivity and 85% specificity for AFP-L3 and 100% for both sensitivity and specificity of OPN. Conclusion: Higher levels of AFP-L3 and OPN in HCC patients than controls propose them as potential markers for diagnosis of this disease. OPN has additional prognostic value through its significant difference among different HCC grades.
[Sawsan Said Hafez, Aziza Ahmed El Sebai, Manal Mohamed Abd AL Aziz, Manal Abdel Baky Mahmoud, Mohamed Omar El Maraghy, Mohamed Omar Khalifa and Nevine Ibrahim Musa. Alfa-Fetoprotein L3 Subfraction and Osteopontin: Novel Markers for the Diagnosis of Hepatocellular Carcinoma. J Am Sci 2013;9(3):322-328]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 56
Keywords: Alpha-fetoprotein-L3, osteopontin, hepatocellular carcinoma, BCLC. Full Text 56