Design, Formulation and Evaluation of Transdermal Ketoprfen Gel
Ahmed M. Samy1, Mamdouh M. Ghorab2, Shadeed G. Shadeed 2 and Eman A. Mazyed3
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
2Department of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
3Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt
Abstract: The aim of this study was to develop Ketoprofen (KPF) gel for tansdermal delivery that could enhance dissolution and permeability of KPF. KPF gels were prepared using Carboxy methyl cellulose (CMC), hydroxyl propyl methyl cellulose (HPMC) and methyl cellulose (MC) with and without permeation enhancers (Tween 80 and Oleic acid). The effect of the employed gel bases and permeation enhancers on the in vitro release, permeation and viscosity of gel formulae was tested. The results showed that both polymers and permeation enhancers affect release, permeation and rheological properties of KPF gel. Formula containing 5% MC and 5 % Tween80 showed the best in-vitro release (98.22% ±1.18), the best permeation through rat skin (96.39% ±3.23) and the lowest viscosity.
[Ahmed M. Samy, Mamdouh M. Ghorab, Shadeed G. Shadeed and Eman A. Mazyed. Design, Formulation and Evaluation of Transdermal Ketoprfen Gel. J Am Sci 2013;9(3):237-242]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 32
Keywords: Ketoprofen, transdermal, permeation, methyl cellulose, Tween80 Full Text 32