Effect of Clomip
Effect of Clomiphene Citrate on the Fallopian Tube of Rats. Histological Considerations and Clinical Implications
Metwally Abd-El-Bary Mansoor
Anatomy Department, Faculty of Medicine, Zagazig University. email@example.com
Abstract: Background: Fallopian tube is a dynamic, steroid responsive tissue that facilitates fertilization of the gamete and early embryo transport. Clomiphene citrate is considered the first line therapy for induction of ovulation in women with anovulatory infertility. There is marked increase in the rate of ectopic tubal pregnancy with clomiphene citrate therapy. Objective: To clarify the histological changes in the tubal mucosa that accompany clomiphene citrate therapy and may predispose to ectopic tubal pregnancy. Material and Methods:Twenty prepubertal female rats were used, they were divided into control group and another group treated with intraperitoneal injections of 10 mg/kg body weight/day of clomiphene citrate for 6 consecutive days. Results:Hypertrophy and hyperplasia of the tubal epithelium with marked ciliogenesis. Marked disturbance of tubal mucosa with shedding of parts of tubal mucosa and mucosal folds into the lumen of the tube. Accumulation of structureless masses in the lumen of the tube. The changes were seen in the tubal ampulla as well as the isthmus.Conclusion: Mucosal disturbance and shedding, epithelial hyperplasia and hypertrophy, luminal masses of shedded epithelium and structurless tissues and disturbance in the function of both epithelial and secretory cells. All the preceeding features may hinder the movement of fertilized ovum and consequently increase the chance for occurrence of ectopic tubal pregnancy.
[Metwally Abd-El-Bary Mansoor. Effect of Clomiphene Citrate on the Fallopian Tube of Rats. Histological Considerations and Clinical Implications. J Am Sci 2013;9(6):197-202]. (ISSN: 1545-1003).http://www.jofamericanscience.org. 23
Key words: Fallopian tube, mucosa, epithelium, clomiphene citrate, histological considerations, rats. Full Text 23