Evaluation of in
Evaluation of inactivated AIV vaccines in conjunction with antiviral drugs in chickens challenged with Egyptian H5N1 HPAIV
Ali, A. Salama; El-Bakry, M. Ismail; Fatma, M. Abdallah and Gemelat, K. Farag
Virology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt
Abstract: The goal of the presented research was to synthesis focuses on the effectiveness of vaccines and antiviral drugs in the prevention and treatment of avian influenza virus (AIV) in chickens. Antibody responses, and virus shedding were evaluated after challenge with Egyptian H5N1 HPAIV (A/chicken/faquos/amn/2/2011 (H5N1)). The results revealed that, the antibody titers in sera of the broiler chickens vaccinated with AI H5N1 vaccine alone or in combination with potent neuraminidase inhibitor antiviral drugs (NAI) were higher than antibody titers in sera of the broiler chickens vaccinated with AI H5N2 vaccine alone or in combination with NAI antiviral drugs against AIV with significant difference (p˂ 0.05). Furthermore, NAI antiviral drugs provided significant protection and reduction the duration and titer of virus shedding especially in vaccinated chickens. These investigations showed that NAI antiviral drugs used in conjunction with vaccination strategies in chicken farms reduced the risk of avian influenza virus.
[Ali, A. Salama; El-Bakry, M. Ismail; Fatma, M. Abdallah and Gemelat, K. Farag. Evaluation of inactivated AIV vaccines in conjunction with antiviral drugs in chickens challenged with Egyptian H5N1 HPAIV. Life Sci J2013;10(1):1962-1968] (ISSN:1097-8135). http://www.lifesciencesite.com. 281
Key Words: HPAIV, H5N1, NAI, H5N2, broiler chickens, antiviral drugs, vaccines. Full Text 281