Protective Activity of Curcumin against Obesity Associated Cardiovascular Disease via Alleviating Leptin and Insulin Resistance
Azza M. El-Wakf*1; El-Sayed M. El-Habibi1 and Abdullah Mogalli2
Faculty of Science, Mansoura University, Mansoura, Egypt1
Faculty of Education, Adan University, Adan, Yemen 2
Abstract: Obesity is one of the leading causes of cardiovascular disease (CVD). This study was designed to evaluate the protective activity of curcumin against incidence of this disease in male rats with diet-induced obesity. For this purpose, male albino rats (175 ± 5g) were fed normal diet or high fat diet (HFD) with or without curcumin (20 mg/kg b.wt.) for duration of 3 months. Feeding rats on HFD caused elevation of the body weight gain and weights of aorta and heart tissue. Meanwhile, HFD-fed rats exhibited marked hyperglycemia, with raised lipid profile as reflected by significant elevation of serum, aorta and heart total lipids (TLs), total cholesterol (TC) and triglycerides (TGs),accompanied by increased serum values of LDL-C, vLDL-C and atherogenic index (AI), with decreased HDL-C level. An increased serum level of leptin and insulin were also observed. The study also showed marked reduction in the antioxidants, superoxide dismutase (SOD) and reduced glutathione (GSH), concomitant with elevation in the level of hydrogen peroxide (H2O2) and lipid peroxidation product, malondialdehyde (MDA) levels in both heart and aorta of HFD-fed rats. Further changes, including elevation of serum aminotranseferases (AST and ALT), lactic dehydrogenase (LDH) and creatinine kinase (CK), with a reduction in their activities in heart and aorta were demonstrated. Also, a reduction in the level of nitric oxide (NO) in the same organs were recorded which together with the above mentioned alterations may indicate developing of cardiovascular disease in association with obesity. On the contrary, administration of curcumin to HFD-fed rats tended to prevent hyperglycemia, hyperlipidemia and other changes relevant to cardiovascular disease mainly through alleviating leptin and insulin resistance. Thus, curcumin can be prescribed as a natural dietary product for reducing risk of CVD in the obese subjects.
[Azza M. El-Wakf; El-Sayed M. El-Habibi and Abdullah Mogalli. Protective Activity of Curcumin against Obesity Associated Cardiovascular Disease via Alleviating. J Am Sci 2013;9(3):397-405]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 64
Key words: Obesity, Curcumin, Leptin, Insulin, Nitric oxide Full Text 64