Losartan versus E
Losartan versus Endoscopic Variceal Ligation (EVL) In Primary Prophylaxis of Variceal Bleeding in Egyptian Cirrhotic Patients: prospective study
Mohamed S. Zakaria, Mohammad S. Abdelbary, Khaled S. Zakaria, Sherif H. Mahmoud Ahmad M. Khairy
Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract: Introduction: esophageal varices (OV) is one of the major complications of portal hypertension in cirrhotic patients, bleeding form varices can be prevented using EVL, moreover blocking the activity of AT II (angiotensin II receptors) may have beneficial effects in lowering portal pressure. This study aimed at assessing Losartan versus EVBL in primary prophylaxis of variceal hemorrhage. Patients & Methods: 40 cirrhotic patients with esophageal varices of grade III to IV were classified into two groups, group I n=20 received Losartan therapy while group II n=20 received EVBL sessions, then patients were followed up after therapy for three months. Results: signs of impending variceal rupture disappeared in both groups with improvement in the grade of varices to become grade I in 100% in group II but only 17.6% in group I, Congestive gastropathy and ascites grades were improved in group I but deteriorated in group II. Conclusion: Both Losartan & EVBL are effective prophylactic to variceal hemorrhage in cirrhotic patients but Losartan was associated with much less complications.
[Mohamed S. Zakaria, Mohammad S. Abdelbary, Khaled S. Zakaria, Sherif H. Mahmoud Ahmad M. Khai.Losartan versus Endoscopic Variceal Ligation (EVL) In Primary Prophylaxis of Variceal Bleeding in Egyptian Cirrhotic Patients: prospective study. J Am Sci 2013;9(6):38-42]. (ISSN: 1545-1003).http://www.jofamericanscience.org. 5
Keyword: Losartan, EVBL, congestive gastropathy, ascites, variceal hemorrhage. Full Text 5