Diagnostic value o
Diagnostic value of ESR, CRP, and PLT in comparison to PCT and C3 in septic ICU cases
Reza Imani Rastabi 1*, Ghorbanali Shahabi2 and Ali Fazel3
1Department of Infectious & Tropical Diseases, Shahrekord University of Medical Sciences, Shahrekord, Iran
2Department of Immunology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Reza Imani Rastabi
Kashani Street, Shahrekord University of Medical Sciences, Shahrekord, Iran
Tel: 98-913-3815531; Fax: 98 381 2221669; Email: firstname.lastname@example.org
Abstract: Sepsis is one of the most common reasons worldwide for death among intensive care unit patients because of diagnostic procedures' limitations. Despite new supportive treatments and administration of high potent antibiotics, sepsis remains fatal and reduces survivors' life quality. To measure Procalcitonin (PCT) and Complement C3 (C3) and their association with Blood Sedimentation (ESR), C-Reactive Protein (CRP), and Leukocytes (WBC) in suspected sepsis patients in Intensive Care Unit (ICU), and use changes in ESR, CRP, and WBC as simple and less expensive tests to diagnose and/or follow up sepsis patients. For this descriptive analytical study, 30 patients with suspected sepsis at ICU were enrolled. ESR, CRP, PLT, and WBC measurements were performed in three stages: admission time (pre-sepsis), in case of onset of possible sepsis indications (peri- sepsis), and prior to discharge (post-sepsis). Serum level of PCT was measured by immunochromatography and C3 determined by SRID. The data was analyzed by repeated measure and Pearson correlation coefficient (SPSS 11). ESR, CRP, PLT, and WBC in peri-sepsis were significantly higher than those in pre- and post sepsis (p <0.05). Comparing PCT mean level in peri- and post-sepsis (lowest level) showed a significant difference, while no significant difference was seen between pre- and peri sepsis (p<0.05). C3 biomarker was also significantly higher in peri-sepsis than pre- and post sepsis (p <0.05). Although changes in PCT and C3 have a high diagnostic value in early stages of sepsis and are used as guides for antibiotic therapy in suspected sepsis cases, regarding the significant difference in ESR, CRP, and WBC in peri-sepsis compared to pre- and post-sepsis in our study, these tests could be offered as simpler and less expensive tests, having moderate diagnostic value for the diagnosis of sepsis on ICU admission.
[Reza Imani Rastabi, Ghorbanali Shahabi and Ali Fazel. Diagnostic value of ESR, CRP, and PLT in comparison to PCT and C3 in septic ICU cases. Life Sci J 2013;10(4s):215-220]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 32
Keywords: Sepsis, Intensive Care Units, Procalcitonin, Blood Sedimentation, C-Reactive Protein, Leukocytes, Complement C3