Dual effect of cur
Elshaimaa M.Ibrahim1 , Abeer M. badr 1, Hiba Sibaii 2, Amany S. E.El-Wakkad 2, Somaya El-Deeb.1
1 Zoology Department, Faculty of Science, Cairo University, Egypt; 2 National Research Center, Dokki, Cairo, Egypt. Corresponding author: firstname.lastname@example.org
Abstract: Objective:To evaluate the effect of methotrexate and curcumin administration on various internal organs in collagen-induced arthritis in rats. Material and methods: Animals were divided into 6 groups, 10 rats each. Group I: Normal control, Group II was injected with DMSO, Group III arthritic rats, Group IV arthritic rats received methotrexate (MTX) (1 mg/ Kg, i.p) once a week and Group V arthritic rats treated with curcumin (100 mg/ Kg, i.p) thrice a week. Group VI was treated with MTX (1 mg/ Kg, i.p) once a week and after 30 min received curcumin (100 mg/ Kg, i.p) thrice a week. Rats were sacrificed and thymus, spleen, liver, lung and kidney were collected for histopathological evaluation. Results: General improvement in examined organs from arthritic rats treated with both MTX and curcumin as compared with other groups. The combination of both MTX and curcumin restored the normal structure of the examined organs. Conclusion: The study showed an effective anti-arthritic action with the combination of MTX and curcumin.
[Elshaimaa M.Ibrahim, Abeer M. badr, Hiba Sibaii, Amany S. E.El-Wakkad, Somaya El-Deeb. Dual effect of curcumin and methotrexate treatment on various organs in collagen-induced arthritis in rats. J Am Sci 2012;8(10):447-454]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 65
Key words: methotrexate , curcumin, arthritis, histopathological investigation Full Text 65