Effect of parenter
1- Department of Pharmacology, Medical Sciences Faculty, Tabriz branch, Islamic Azad University, Tabriz, Iran.
3- Department of surgery, Faculty of veterinary medicine, Tabriz branch, Islamic Azad University, Tabriz, Iran.
Abstract: Introduction: Analgesic efficacy of parenterally acetaminophen is variable in different surgical procedures. Little data is available on its efficacy in Colectomy. Intravenous Acetaminophen is a useful drug in treating postoperative pains and could be used alone or in combination with other drugs. Current study conducted this prospective, randomized, double blind study to evaluate and compare the efficacy acetaminophen with morphine in Colectomy surgery over a 24 hour period. Methods: In a clinical trial, 79 patients candidate for elective lumbar Colectomy were randomly put into groups receiving Acetaminophen (40 patients) or placebo (39 patients). In group one, 1 gr I.V.Acetaminophen infusion started 15 minutes before the end of surgery. Group 2 received 100 ml NaCl 0.9% in the same period. Pain scores were assessed at relaxation with VAS (visual analogue scale) at 0 (after awakening), 5, 10, 15 and 24 hours. Morphine use (according to patient's will due to pain) was recorded in 24 hours. Results: Acetaminophen group had significantly lower mean VAS (less sever pain) than placebo group after recovery (5.73±1.89 versus 6.85±2.11, p=0.004), 5 hours later (5.34±2.03 versus 7.67±1.9, p=0.01), 10 hours later (4.81±1.29 versus 5.71±1.31, p=0.02), 15 hours later (4.11±1.05 versus 4.67±1.61, p=0.02) and 24 hours later (2.61±1.31 versus 3.57±1.41, p=0.01). Morphine requirement in different periods was lower in Acetaminophen group than placebo which had no significant differences. Mean cumulative morphine use in 24 hours in paracetamol group (5.89±2.79 mg) was lower than placebo group (8.48±3.51 mg), however the difference was not significant. Conclusion: Results of current study showed that intravenousAcetaminophen is effective in reducing postoperative pain severity, but do not reduces need for morphine use.
[Eilyad Issabeagloo, Babak Abri Aghdam, Ali Rezaei. Evaluation of effect of Acetaminophen on the lessen of post operative pain due to Colectomy in parenterally administration. Life Sci J 2013;10(4s):308-313] (ISSN:1097-8135).http://www.lifesciencesite.com. 45