Electrogastrographic (EGG) and Gastric Emptying Changes in Patients with Duodenal Ulcer .The Effect of H. Pylori Eradication
Samia A. Abdo1, HishamS. Abdel Fattah2, Uomna Kamel3
1Gastroenterology unit, Faculty of Medicine, Ain shams University, Cairo, Egypt
2Faculty of Medicine, Misr University For Science And Technology
3Faculty of Medicine, 6 October University , Cairo, Egypt
Abstract: Helicobacter pylori infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are now generally accepted as critical factors in the pathogenesis of peptic ulcer (PU). Helicobacter pylori(H. Pylori) infection is associated with over 90% of duodenal ulcer. Helicobacter Pylori infection may result in several alternation of gastro-duodenal physiology. Aim of the work: was to study the possible gastric myo-electrical activity changes in patients with H. Pyloriassociated duodenal ulcer and their relation to gastric emptying, as well as the effect of H. Pylorieradication on such changes. Patients and methods: 60 subjects were enrolled in this study and classified into three groups: Group I: Twenty patients with H. Pyloriinfection associated with duodenal ulcer Group II: Twenty patients with H. Pylorinegative duodenal ulcer. Grouplll: Twenty age and sex matched "healthy" asymptomatic volunteers; ten positive and (llla) ten negative (lllb) for H. Pylori. For all patients; complete history and physical examination, upper endoscopy and pyloric antral biopsy for H. Pyloridetection, abdominal ultrasound, and electro-gastrogram were performed. Results: in group I patients mean of power ratio (PR) was lower than that of group IIIa (1.42±0.74 versus 2.94±1.9 (P<0.01), while, gastric emptying parameters showed insignificant difference. No significant difference was found between group II and group IIIb as regards EGG parameters, while full time and ½ empting time in-group II was significant by lower than group IIIb. (13±2.8min, 15.7±2.8min. respectively P<0.05, and 4.89±2.2min, versus 6.7±2.48min for ½ empting time P<0.05). After eradication therapy 87% of our patients became negative for H. Pylori, EGG repeated for group 1 patients after eradication. The mean of % power at rest, The mean of %CPM at meal, and The mean of PR was significantly lower before than after treatment(P<0.05, <0.05. &<0.01). The mean of power at rest of DF was statistically significant higher before than after treatment P<0.01. Mean of 1/2 in-group I patients was higher before than after eradication therapy). Conclusion: Helicobacter pylori infection can affect gastric motility, especially in duodenal ulcer infected patients. Eradication therapy improved not only EGG abnormalities but also aids in restoration of abnormal water gastric emptying.
[Samia A. Abdo, HishamS. Abdel Fattah and Uomna Kamel. Electrogastrographic (EGG) and Gastric Emptying Changes in Patients with Duodenal Ulcer. The Effect of H. Pylori Eradication. Life Sci. J2013;10(1):3081-3088]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
Keywords: Electrogastrography (EGG), gastric motility, Helicobacter Pylori, duodenal ulcer.