Ahmed A. El-Kateb1, Naglaa M. Abd El-Rahman1,2,*, Tamer S. Saleh1,3, Ibrahim F. Zeid4, Mohamed F. Mady1
1Green Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt
2Chemistry department, Faculty of Science, Jazan University, Jazan, Saudi Arabia
3Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, Saudi Arabia
4Chemistry Department, Faculty of Science, El-Menoufia University, Shebin El-Koam, El-Menoufia, Egypt
Abstract: A facile, rapid and efficient microwave-assisted procedure for the synthesis of novel pyrazole, pyrimidine, and pyrazolo[1,5-a]pyrimidines linked to sulfonyl dibenzene moiety via the reaction of E-3-(N,N-dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one 3 with the appropriate amines described here. In general, microwave procedure as an eco-friendly energy source offers advantages such as a shorter reaction time, simple workup, reaction selectivity and improves an overall yield compared with conventional methods. The structures of all the compounds were confirmed by analytical and spectral data.
[Ahmed A. El-Kateb, Naglaa M. Abd El-Rahman, Tamer S. Saleh, Ibrahim F. Zeid, Mohamed F. Mady. Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety.Life Sci J 2012;9(1):711-718]. (ISSN: 1097-8135). http://www.lifesciencesite.com.102
Keywords: Green chemistry; enaminone; pyrazolo[1,5-a]pyrimidine; aryl Sulfone; microwave irradiation Full Text 102