Prognostic Significance of Angiopoitein-2 in patients with Chronic Lymphocytic Leukemia
Zahra M.K(1)., Eissa.S.A.(1) Tawfik. H.(2), Amira. Y. Abd-Elnaby.(1), Tawfik.S. (3), Badr.E.A.,(1) and
Wageih. S. ELnaghy(4)
(1)Clinical Pathology Dept., Faculty of Medicine, Tanta University,(2) Oncology Department, Faculty of Medicine, Tanta University s(3)Internal medicine Dept., NRC, (4) Microbiology department, Faculty of Medicine Tanta University.
Abstract: Introduction: Chronic lymphocytic leukemia is a lymphoproliferative disorder characterized by progressive lymphocytosis in the blood, bone marrow and lymphatic tissue. Angiopoietin-2 is a member of the angiopoietin family, which plays an important role in angiogenesis, the formation of blood vessels from pre-existing blood vessels. This study tried to throw light on the behavior of serum Ang-2 in newly diagnosed B-CLL searching for possible value for its estimation. Patients and method: The present study was conducted on 40 individuals. They were subdivided into two groups: Control group: Included 10 healthy individuals. Patient group: They were 30 newly diagnosed chronic lymphocytic leukemia patients. Patients and controls were subjected to history taking and clinical examination laying stress on splenomegaly, hepatomegaly and lymphadenopathy. Laboratory investigations including; complete blood picture, ESR, serum lactate dehydrogenase, kidney function tests, liver function tests, estimation of serum angiopoitein-2 by ELISA technique. Absolute lymphocyte count, bone marrow aspiration and Immunophenotypeing were performed in patients only. Results: There was statistical significant decrease in hemoglobin level and platelets counts in patients group as compared to control. However, TLC and ESR were increased significantly in patients as compared to control group. According to Rai classifications; ESR, Absolute lymphocytic count, TLC, and absolute lymphocytic count, the percentage of lymphocytes in BM, serum LDH, serum Ang-2 levels, and percentage of CD38 expression showed significantly progressive increase all through stages However Platelet count and Hb level showed significantly progressive decrease with the progress of the stages. There was a significant positive correlation between the level of Ang-2 and the stage of CLL, CD38, total leucocytic count,percentage of lymphocytes in BM and LDH in CLL patients. In conclusion, the present study shows that circulating levels of Ang-2 were higher in CLL patients at diagnosis in comparison with apparently healthy individuals
[Zahra M.K, Tawfik.H, Eissa.S.A , Amira.Y .Abd-Elnaby, Tawfik.S, Badr.E and Wageih.S. ELnaghy. Prognostic Significance of Angiopoitein-2 in patients with Chronic Lymphocytic Leukemia. Life Sci J 2013;10(1):2726-2730] (ISSN:1097-8135). http://www.lifesciencesite.com.
Key words: Angiopoitein-2, Chronic lymphocytic leukemia (CLL).