Protective Effect of Rosemary (Rosmarinus Officinalis) Leaves Extract on Carbon Tetrachloride -Induced Nephrotoxicity in Albino Rats
Saber A. Sakr1 and Hawazen A. Lamfon2
1. Zoology Department, Faculty of Science, Menoufia University, Egypt
2. Department of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
Abstract: Carbon tetrachloride (CCl4) is an environmental pollutant that showed toxicity in different organs. Exposure to CCl4 is known to induce the formation of reactive oxygen species (ROS). Rosemary (Rosmarinus officinalis) is a herb commonly used as spice and flavoring agents in food processing and is useful in treatment of many diseases. The purpose of present study was to investigate the protective role of rosemary on CCl4-induced renal damage. Treating rats with 1.0ml /kg body weight of 10% CCl4 twice a week for 6 weeks induced many histological changes in the kidney cortex .The renal tubules lost their characteristic appearance and their lining epithelial cells were degenerated. The glomeruli were atrophied and the renal blood vessels were congested. The intertubular spaces were infiltrated by inflammatory leucocytic cells. An increase in interstitial expression of α-SMA was observed compared with control group. CCl4 also caused marked elevation in serum creatinine and urea. Treating animals with CCl4 and aqueous extract of rosemary led to an improvement, in both biochemical and histopathological pictures. It is concluded that rosemary extract had a protective effect against kidney injury induced by CCl4 and this effect may be attributed to its antioxidant activity.
[Saber A. Sakr and Hawazen A. Lamfon. Protective Effect of Rosemary (Rosmarinus Officinalis) Leaves Extract on Carbon Tetrachloride -Induced Nephrotoxicity in Albino Rats. Life Sci J 2012; 9(3):779-785]. (ISSN: 1097-8135).http://www.lifesciencesite.com.112
Keywords: CCl4, Rosemary, Nephrotoxicity, Creatinne, urea, α-SMA Full Text 112