1 Zoology Department, Faculty of Science, Cairo University, Egypt; 2 National Research Center, Dokki, Cairo, Egypt. Corresponding author: firstname.lastname@example.org
Abstract: Objective: To evaluate the protective effect of curcumin administration on various internal organs in collagen-induced arthritis in rats. Material and methods: Animals were divided into 4 groups, 10 rats each. Group I: Normal control, Group II was injected with DMSO, Group III arthritic rats, Group IVarthritic rats received curcumin (100 mg/ Kg, i.p) thrice a week for 7 weeks prior to induction of arthritis. Rats were sacrificed and thymus, spleen, liver, lung and kidney were collected for histopathological evaluation. Results: Mild improvement in examined organs from rats injected with curcumin prior to induction of arthritis as compared with arthritic group. Curcumin minimized the complications caused by arthritis on the examined internal organs. Conclusion:The study showed that the administration of curcumin prior to induction of arthritis, to a certain extent minimized the complications caused by the disease on the internal organs under study.
[Elshaimaa M.Ibrahim, Abeer M. badr, Hiba Sibaii, Amany S. E.El-Wakkad ,Somaya El-Deeb. Protective effect of curcumin treatment on some organs in collagen-induced arthritis in rats. J Am Sci2012;8(10):413-419]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 60
Key words: curcumin, arthritis, histopathological evaluation. Full Text 60