2- Department of surgery, Faculty of Veterinary Medicine, Tabriz branch, Islamic Azad University, Tabriz, Iran.
Abstract: (RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone with generic name of Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative in addition to it’s sedative, analgesic anti bronchospasmand anti depressant effects. Diphenhydramine is a influential first-generation antihistamine possessinganticholinergic, antitussive, antiemetic, and sedative properties which is mainly used to treat allergies. It also has a powerful hypnotic effect, and for this reason is often used as a non-prescription sleep aid. Thereupon it seems that co administration of Diphenhydramine and ketamine cause more effective & deep CNS depression effects and also alleviate some of ketamine adverse effects. The aim of this study was evaluation of ketamine and Diphenhydramine CNS suppression effects in the manner of single and concomitant administration. Ten free roaming male & mature cats as animal model received mentioned drugs via enteral route. Each animal was monitored continually by educated expert for CNS depression signs as graded on the behavioral scales.Diphenhydramine alone in oral administration of any Doses could induce only suitable sleep with Immobility in animals. But ketamine in different doses showed a significant dose dependent CNS suppression effect. Concomitant use of Diphenhydramine with ketamine promoted CNS depression effects of ketamine.
[Eilyad Issabeagloo, Ali Rezaei. (RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone has forcefully effect on CNS whenever be administrated Enterally with Diphenhydramine as a potent classic antihistamine. Life Sci J 2013;10(1):886-894]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
KEY WORDS: Ketamine, Diphenhydramine, CNS depression, enteral route, Animal model