Synthesis and Some
Synthesis and Some Reactions of Some New Benzofuran Derivatives with Possible Biological Activity
Nadia M. Saleh
Chemistry Department Faculty of Science (Girls) Al-Azhar University, Nasr City, Cairo, Egypt
Abstract: 3-[4-Methoxy-6-hydroxy-5-benzofuranyl] and 3-[4,6-dimethoxy-5-benzofuranyl] 1,3-diketo byrate (1a,b)(1) were obtained from the reaction of [4-hydroxy (or methoxy) benzofuran-5-yl] methyl ketone (Aa,b) with ethyl acetate in presence of sodium metal. (1a,b) were reacted with α-cyanothioacetamide in the presence of ammonium acetate(2) to give mercapto-3-carbonitrile-4-methyl-6-[4-methoxy-6-hydroxy-5-benzofuranyl] pyridine (2a) and 2-mercapto-3-carbonitrile-4-methyl-6-[5,6-dimethoxy-5-benzofuranyl] pyridine (2b) (or possible isomers (3a,b) respectively for the preparation of some novel benzofuran derivatives (4a,b), (5a,b), (6a,b), (7a,b), (8a-d), (9a,b) and (10a,b). On the other hand sterylketone (11a-c) were obtained by condensation of (Aa,b) with aromatic aldehyde. Compounds(11b,c) gave new benzofuran derivatives (12a,b), (13), (15), (16) and (17). Selected members of the prepared compounds were screened for antimicrobial and antifungal activities.
[Nadia M. Saleh. Synthesis and Some Reactions of Some New Benzofuran Derivatives with Possible Biological Activity. J Am Sci 2012;8(10):300-307]. (ISSN: 1545-1003). http://www.jofamericanscience.org.44
Keywords: New benzofuran derivatives are starting material for the preparation of heterocyclic compounds containing benzofuran moieties Full Text 44