The Effect Of Asco
2- Department of physiology, Medical Sciences Faculty, Tabriz branch, Islamic Azad University, Tabriz, Iran.
ABSTRACT: Pentanedioic acid derivatives such as Methotrexate are anti-neoplastic agents and are widely used in treatment of auto immune disorders and malignant diseases, but their use is limited because of several side effects including hepatotoxicity. As one of the important mechanisms involving in the pathogenesis of methotrexate toxicity, some of anti-oxidant agents have been used to reduce its side effect. Ascorbic acid (Vit. C) is an important anti-oxidant drug and in this research we aimed to study vitamin C effect on methotrexate induced hepatotoxicity. Thirty male Wistar rats were divided into three groups (n=10). First group was control group, the second group was Methotrexate group (represent pentanedioic acid derivatives) in which received, and the third group was methotrexate plus vitamin C group whom received methotrexate and vitamin C. On 6th day, the rats were anesthetized and liver tissue removed for pathologic studying and plasma isolated for measuring ALT and AST (P<0.05). Results showed that vitamin C treatment decreased liver tissue injury and elevation of ALT and AST after methotrexate administration. Regarding increasing use of methotrexate and the results of this research Vitamin C may be helpful in suppressing methotrexate induced hepatotoxicity and it is suggested to do this research on other animal models and study the underlying mechanisms.
[Ramin Amin Abad, Naiyereh haeri Far, Eilyad Issabeagloo. The Effect Of Ascorbic Acid On Protection Of Hepatic Injury Consequence Effective Isomers Of Pentanedioic Acid In Rats. Life Sci J 2013;10(7s):589-592]. (ISSN: 1097-8135).http://www.lifesciencesite.com. 94
Key words: hepatotoxicity; ascorbic acid; pentanedioic acid derivatives; Methotrexate; Rat.