Liquid
Liquid based endometrial cytology in diagnosis of
high-grade endometrial carcinoma with emphasis in recent advances and tissue
correlation
Dastranj Tabrizi Ali1,
Vahedi Amir1, Esmaiely Heidar Ali1, Sayyah Melli
Maniegheh1, Jafari shobeiri Mehri1, Mostafa Gharabaghi
Parvin1, Ouladehsahebmadarek Elahe1, Ghojazadeh Mortaza1, Khaki
Arash2¬
1- Women’s Reproductive
Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Pathology,
Tabriz Branch, Islamic Azad University, Tabriz, Iran
Correspondence
Author: [email protected]
Abstract: Background:
Invasive endometrial cancer is the most common cancer of the female genital
tract and from clinico-pathologic standpoint endometrial serous carcinoma as a
prototype of type II endometrial carcinomas, has poor prognosis and 46% of
these tumors are going to be diagnose in metastatic and high stages. The aims
of this research is comparison of endometrial cytological findings in high
grade endometrial carcinoma with tumor histology and achieve accuracy,
sensitivity, specificity, positive predictive value and negative predictive
value of this method in diagnosis of high grade endometrial tumors. Methods:
Seventy patients, who had been candidate for hysterectomy, underwent for
endometrial brush cytology before surgery. The prepared liquid based cytology
smears examined by gynecological pathologist and the cytologic findings
compared with histologic results and stages in a blind fashion. Results: All 12
cases of high- grade malignant lesions diagnosed by permanent histologic
sections were diagnosed by cytological smears except one. There was complete
correlation between cytologic and histologic findings regarding to tumor type
and nuclear grades. The accuracy, sensitivity, specificity, PPV and NPV of
endometrial brush cytology were calculated as 98%, 91%, 100%, 100% and 98%
respectively. Conclusion: Endometrial cytology is a simple and feasible method
for diagnosing of endometrial malignant lesions and if this high sensitivity
and specificity be achieved in diagnosis of endometrial premalignant lesions
such as endometrial intraepithelial neoplasia (EIN) and endometrial glandular
dysplasia (EmGD) in large studies, it may be useful in early diagnosis and
screening of endometrial lesions.
[Dastranj
Tabrizi Ali, Vahedi Amir, Esmaiely Heidar Ali, Sayyah Melli Maniegheh, Jafari
shobeiri Mehri, Mostafa Gharabaghi Parvin, Ouladehsahebmadarek Elahe,
Ghojazadeh Mortaza, Khaki Arash. Liquid based endometrial
cytology in diagnosis of high-grade endometrial carcinoma with emphasis in recent
advances and tissue correlation. Life Sci J2013;10(4s):432-435]
(ISSN: 1097-8135). http://www.lifesciencesite.com. 66
Keywords: Endometrial Cancer, Endometrial Intraepithelial
Neoplasia, Endometrial Cytology.
