Effect
Effect of Exogenous Estrogen during Pregnancy on the
Development of the Testis of Rats. Histological Considerations and Clinical
Implications
Metwally
Abd-El-Bary Mnsoor
Anatomy
Department, Faculty of Medicine, Zagazig University
Abstract: Background: Testicular dysgenesis syndrome is a
result of disruption of embryonal programming and gonadal development during
fetal life. In recent years, evidences have accumulated that exposure to
environmental components with estrogenic activity causes reproductive disorders
in human population.Objective: The study was carried out to
evaluate the testicular hazards of the neonatal rats resulting from exposure of
their pregnant mothers to estrogenic compounds. Subjects: Two
primary groups, each consisted of 3 adult male and 12 adult female rats were
used. After mating, two secondary groups, each consisted of 6 pregnant rats
were divided into control group injected with saline and treated one, subcutaneously
injected with oestradiol benzoate 100 mg/kg. body weight/day from the 13th day of
pregnancy onwards. Results: There is marked decrease in
seminiferous tubules of the testis. Some tubules are incompletely formed with
blood cells in interstitial tissue of the testis. The nuclei of spermatogenic
cells are markedly affected beginning from disturbance in their shapes and
chromatin distribution, to pyknosis, to complete disappearance. Their cytoplasm
was vacuolated. Sertoli cells showed vacuolation of their cytoplasm and the
nuclei of Leydig cells are more heterochromatic. Conclusion:
Estrogenic compounds administered to pregnant mothers produce marked
histological hazards in the testes of their neonates and so, estrogenic
compounds must be avoided as possible during pregnancy.
[Metwally Abd-El-Bary Mnsoor. Effect of Exogenous Estrogen
during Pregnancy on the Development of the Testis of Rats. Histological
Considerations and Clinical Implications. J Am Sci 2013;9(6):245-250].
(ISSN: 1545-1003). http://www.jofamericanscience.org. 28
Key
words: Oestradiol,
Testis, Histological study, Albino rats. Full Text 28
