Carbonic
Carbonic
Anhydrase and Urease Inhibitory Effects of Sonchus Asper
Ihsan Ullah Khan1, Jameel A. Khader2 , Farman Ullah
Khan3, Arif Ullah Khan4, Muhib Ullah5,
Syed Badshah3,Naser M. AbdEIslam2, Hidayatullah
Khan6, Riaz Ullah7*
1Department of Chemistry, Quaid-e-Azam University
Islamabad Pakistan
2Arriyadh Community College, King Saud
University, Riyadh, Saudi Arabia
3Department of Chemistry, University of Science and
Technology Bannu -28100, KPK, Pakistan
4Department of Pharmacy, Kohat University of Science
and Technology Kohat KPK, Pakistan
5Department of Zoology, Kohat University of Science and
Technology Kohat, KPK Pakistan
6Department of Biotechnology, University of Science and
Technology Bannu -28100, KPK, Pakistan
7Department of Chemistry, Sarhad University of Science
and Information Technology Peshawar KPK Pakistan
Corresponding author; Dr
Riaz Ullah. [email protected]
Abstract: In
present research, an attempt was made to explore the pharmacological potential
of Sonchus asper. The crude extract of Sonchus asper and
its resultant fractions were tested for the carbonic annhydrase and urease
inhibitory actions. The chloroform fraction of Sonchus asper exhibited maximum
carbonic anhydrase II inhibition of 58.0%, followed by the plant crude extract,
n-hexane fraction and aqueous fraction with 42.6, 30.2 and 21.3% inhibition
respectively. In urease inhibitory bioassays, n-hexane fraction possesses
highest urease inhibition capacity of 24.1%, followed by chloroform fraction
(19.1%), crude extract (5.4%) and aqueous fraction (3.4%). These results
indicate that Sonchus asper exhibits carbonic anhydrase and
urease inhibitory activities. The higher carbonic anhydrase and urease
inhibitory profile observed respectively for chloroform and n-hexane fractions
of Sonchus asper propose concentration of respective active
compounds, which warrants further detail studies for their isolation and
molecular identification. [Ihsan Ullah Khan, Jameel
A. Khader , Farman Ullah Khan, Arif Ullah Khan, Muhib Ullah, Syed
Badshah, Naser M. AbdEIslam, Hidayatullah
Khan, Riaz Ullah. Carbonic Anhydrase and Urease Inhibitory Ef fects of Sonchus
Asper. Life Sci J2013;10(1):2705-2707]
(ISSN:1097-8135). http://www.lifesciencesite.com.
Key words: Sonchus asper, carbonic anhydrase, and urease inhibition.
