Cytotoxi
Cytotoxic
activity of Buddleja
asiatica
Mona Mohamed*1,
Allia Abdou1, Amal Saad1, Magda Ibrahim2
1Medicinal Chemistry Department, Theodor Bilharz
Research Institute (TBRI),
2Pharmcognosy Department,
Azhar University
Abstract: Phytochemical
investigations of Buddleja asiatica leaves have led to the
isolation of a new compound: 3,4 dihydroxy phenylethyl alcohol 8-O[(4'-O-feruoyl)-α-L-rhamnopyranosyl-(1''→3')
–β-D-glucopyranosyl-(1'''→6')]- β-D-glucopyranoside 1, along with 5
known metabolites: E-acteoside, E-iso acteoside, rutin,
trimethoxy luteolin and ajugol. All metabolites were isolated for the first
time from the genusBuddleja. The
structures were determined by spectroscopic methods (UV, ESI-MS, 1H, 13CNMR, 1H-1H
COSY, HSQC, and HMBC). The investigated methanol extract and compounds (1-4) showed
significant cytotoxic activity against a HepG2 cell line.
[Mona Mohamed, Allia Abdou, Amal Saad,and
Magda Ibrahim. Cytotoxic activity of Buddleja asiatica. Life Sci J 2013;
10 (1):2773-2777]. (ISSN: 1097-8135). http://www.lifesciencesite.com.
Key words: Buddleja asiatica, Cytotoxic, HepG2.
