Guggul R
Guggul Resin Extract Improve hyperglycemia and Lipid
Profile in Streptozotocin Induced Diabetes Mellitus in rats
Widad
M. Al- Bishri1, Omar S. Al-Attas 2, 3
1Department
of Biochemistry, Sciences Faculty for Girls, King Abdulaziz University, Jeddah
21589, Saudi Arabia
2Department
of Biochemistry, College of Science, Po Box 2455, King Saud University, Riyadh
11451, Saudi Arabia
3Center of
Excellence in Biotechnology Research, Po Box 2460, King Saud University, Riyadh
11451, Saudi Arabia
Abstract: Natural products is an affective approach
for the treatment of diabetes and prevention of associated complications. The
objective of the current study is to explore the potential impact of guggul
resin aqueous extract (GRE) obtained from Commiphora mukul against
hyperglycemia and associated metabolic disorders in streptozotocin (STZ)
induced diabetes in rats. The results showed that oral administration of GRE
(40 mg/kg body weight) to diabetic rats effectively reduced the elevated plasma
glucose and glycosylated hemoglobin (HbA1c ) levels and up-modulated the
decrease in C-peptide and insulin levels compared to normal rats. The plant
extract also successfully reduced the elevated plasma lipids including
triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL-C)
and modulated the decrease in the high density lipoprotein (HDL-C), and the
associated hypertension in diabetic rats versus normal ones. The result also
showed that the plant extract was effective in ameliorated plasma adeponectin
of diabetic rats versus normal ones. Plasma homocysteine was lowered in
diabetic animals compared to control ones, however, non significant change in
its level was observed between diabetic animals and diabetic-GRE treated group.
In conclusion, the present study proved that GRE has good glycemic control
which may related to its antioxidant potential action, hence with its
antioxidant activity, treatment with this plant extract can be effective in
treatment of diabetes and associated disorders.
[Widad M. Al- Bishri and
Omar S. Al-Attas. Guggul Resin Extract Improve hyperglycemia and Lipid
Profile in Streptozotocin Induced Diabetes Mellitus in rats. Life
Sci J 2013;10(1):2735-2741] (ISSN:1097-8135).http://www.lifesciencesite.com.
Keywords: Commiphora mukul, diabetes, metabolic disorders, adeponectin.
