Interact
Interactive
Role of Obesity and Other Risk Factors in Egyptian Subjects with Coronary
Artery Disease
Azza M. ElWakf 1*;
AfafAbd El Hafez 2; Afaf M. El Saied3 and Sahar
M. Hussien1
1Zoology Department, Faculty of Science, Mansoura
University, Mansoura, Egypt
2Cardiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Genetics Unit, Children Hospital, Faculty of Medicine,
Mansoura University, Egypt
Abstract:Coronary artery disease (CAD) is a leading cause of
morbidity and mortality worldwide. Obesity has been suggested as a major risk
factor for this disease. This study aims to assess the relation between
obesity and CAD in a selected group of Egyptian population. Other risk factors,
including blood pressure, blood glucose, and lipids have also been
investigated. The study included 80 patients with CAD (mean
age: 47.86 years, males / females: 43/37), and 40 healthy
controls (mean age: 46.15 years, males / females: 13/27).
CAD patients were divided according to their body mass index (BMI) into 2 main
groups: normal weigh group (BMI: 18.5–24.9, n=40) and abnormal weight
group (BMI≥25, n= 40), the latter group was further sub-divided
into overweight group (BMI: 25.0–29.9, n= 20) and obese group (BMI≥
30, n= 20).The study revealed marked increase in systolic blood
pressure (SBP), and diastolic blood pressure (DBP) among CAD patients compared
to normal subjects. Significant increase in serum lipids [total cholesterol
(TC), triglycerides (TGs), low density lipoprotein cholesterol (LDL-C)] and
glucose, as well as blood glycosylated hemoglobin (HbA1c) % were also recorded.
This goes in parallel with a reduction in high density lipoprotein cholesterol
(HDL-C) and NO level in all CAD patients. However, these changes together
seemed to be more drastic in the obese patients comparing with control and CAD
patients with normal and overweight profile. So, it can conclude that obesity
confers independent risk factor for CAD, probably through influencing
interaction with the traditional risk factors, such as hypertension,
dyslipidemia and hyperglycemia.
[Azza M. El Wakf;
AfafAbd El Hafez; Afaf M. El Saied and Sahar M. Hussien. Interactive
Role of Obesity and Other Risk Factors in Egyptian Subjects with Coronary
Artery Disease. J Am Sci 2012;8(10):43-50]. (ISSN:
1545-1003). http://www.jofamericanscience.org. 8
Key words: Coronary artery disease, Obesity, Nitric oxide. Full Text 8
